HC of MSH2 on an FFPE Colon Carcinoma Tissue

IHC of MSH2 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation MSH2 is a mismatch repair gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. When cloned, it is a human homolog of the E. coli DNA mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 is abnormally deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition found in Hereditary Non-Polyposis Colon Cancer. This anti-MSH2 antibody (along with MLH1 antibody) is useful in screening patients and families for this rare condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Antibody Type Mouse Monoclonal Clone G219-1129
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Nuclear Control Colon, Skin, Breast, Tonsil, Fallopian Tube, Colon Carcinoma
Presentation Anti-MSH2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5771 Prediluted Ready-To-Use 3.0 ml
BSB 5772 Prediluted Ready-To-Use 7.0 ml
BSB 5773 Prediluted Ready-To-Use 15.0 ml
BSB 5774 Concentrated 1:50-1:200 0.1 ml
BSB 5775 Concentrated 1:50-1:200 0.5 ml
BSB 5776 Concentrated 1:50-1:200 1.0 ml
BSB 5777 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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