IHC of MSH2 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation MSH2 is a mismatch repair gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. When cloned, it is a human homolog of the E. coli DNA mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.
MSH2 is abnormally deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition found in Hereditary Non-Polyposis Colon Cancer. This anti-MSH2 antibody (along with MLH1 antibody) is useful in screening patients and families for this rare condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Antibody Type Rabbit Monoclonal Clone RBT-MSH2
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Colon Mucosa, Colon Carcinoma
Presentation MSH2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6926 Prediluted Ready-To-Use 3.0 ml
BSB 6927 Prediluted Ready-To-Use 7.0 ml
BSB 6928 Prediluted Ready-To-Use 15.0 ml
BSB 6929 Concentrated 1:50-1:200 0.1 ml
BSB 6930 Concentrated 1:50-1:200 0.5 ml
BSB 6931 Concentrated 1:50-1:200 1.0 ml
BSB 6932 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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