IHC of Mesothelin on an FFPE Ovarian Tissue

IHC of Mesothelin on an FFPE Ovarian Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Mesothelin was first identified by its reactivity with monoclonal antibody K1. The mesothelin gene encodes a precursor protein that is processed to yield mesothelin, which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-KDa shed fragment named megakaryocyte-potentiating factor (MPF). Its biological function is not known, but recent studies have shown that mesothelin forms a strong and specific complex with MUC16, which has been suggested to be the basis of ovarian cancer metastasis.
Mesothelin is present on normal mesothelial cells lining the pleura, peritoneum, and pericardium. In tumors, overexpression of Mesothelin has been observed in mesotheliomas, and other tumors including ovarian, pancreatic carcinomas, and cholangiocarcinoma.
Antibody Type Rabbit Monoclonal Clone EP140
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Cervix, Tonsil, Mesothelioma, Ovarian Cancer
Presentation Mesothelin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6919 Prediluted Ready-To-Use 3.0 ml
BSB 6920 Prediluted Ready-To-Use 7.0 ml
BSB 6921 Prediluted Ready-To-Use 15.0 ml
BSB 6922 Concentrated 1:50-1:200 0.1 ml
BSB 6923 Concentrated 1:50-1:200 0.5 ml
BSB 6924 Concentrated 1:50-1:200 1.0 ml
BSB 6925 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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