IHC of Melanoma Cocktail on an FFPE Melanoma Tissue

IHC of Melanoma Cocktail on an FFPE Melanoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation HMB-45 reacts against an antigen present in immature melanosomes, cutaneous, melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. This antibody is very useful to identify Malignant Melanoma.
MART-1/Melan-A is a protein antigen found on melanocytes. Antibodies against this antigen are used to recognize cells of melanocytic differentiation, useful for the diagnosis of Melanoma. The same name is used to refer to the gene which codes for this antigen. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation.
The MART-1/Melan-A antigen is specific for the melanocyte lineage found in normal skin, retina, and melanocytes, but not in other normal tissues. It is thus useful as a marker for Melanocytic Tumors, with the caveat that it is normally found in benign nevi as well. Anti-Tyrosinase has been found to be quite specific for melanotic lesions such as Malignant Melanoma and Melanotic Neurofibroma. Essentially no carcinomas express this marker. Melanoma cocktail HMB-45, Mart-1 and Tyrosinase are ideally suited to detect melanomas and melanocytic lesions and may prove to be a valuable marker for melanoma metastasis in sentinel lymph nodes.
Antibody Type Mouse Monoclonal Clone HMB-45, A103 & BSB-6
Isotype IgG1/K, IgG1 & IgG2a Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Skin, Melanoma
Presentation Melanoma Cocktail is a mouse monoclonal antibody cocktail derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6877 Prediluted Ready-To-Use 3.0 ml
BSB 6878 Prediluted Ready-To-Use 7.0 ml
BSB 6879 Prediluted Ready-To-Use 15.0 ml
BSB 6880 Concentrated 1:100-1:500 0.1 ml
BSB 6881 Concentrated 1:100-1:500 0.5 ml
BSB 6882 Concentrated 1:100-1:500 1.0 ml
BSB 6883 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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