IHC of MDR-1 on an FFPE Tissue

IHC of MDR-1 on an FFPE FFPE Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation P-glycoprotein 1, also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243), functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance phenomenon observed in human cancer cells following prolonged chemotherapy. The classic form of multiple drug resistance is associated with an increase in the MDR protein, but not in all cases. MDR-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug transport pump that transports a variety of drugs from the brain back into the blood.

MDR-1 is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.

Antibody Type Mouse Monoclonal Clone JSB-1
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Skeletal Muscle, Kidney, Adrenal, Liver
Presentation MDR-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6898 Prediluted Ready-To-Use 3.0 ml
BSB 6899 Prediluted Ready-To-Use 7.0 ml
BSB 6900 Prediluted Ready-To-Use 15.0 ml
BSB 6901 Concentrated 1:25-1:100 0.1 ml
BSB 6902 Concentrated 1:25-1:100 0.5 ml
BSB 6903 Concentrated 1:25-1:100 1.0 ml
BSB 6904 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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