MDR-1-20X-1GEL02-23-1 Adrenal

IHC of MDR-1 on an FFPE Adrenal Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation P-glycoprotein 1, also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243), functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance phenomenon observed in human cancer cells following prolonged chemotherapy. The classic form of multiple drug resistance is associated with an increase in the MDR protein, but not in all cases. MDR-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug transport pump that transports a variety of drugs from the brain back into the blood.

MDR-1 is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier.

Antibody Type Rabbit Monoclonal Clone EP271
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Skeletal Muscle, Kidney, Adrenal, Liver
Presentation MDR-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2531 Prediluted Ready-To-Use 3.0 ml
BSB 2532 Prediluted Ready-To-Use 7.0 ml
BSB 2533 Prediluted Ready-To-Use 15.0 ml
BSB 2534 Concentrated 1:50-1:200 0.1 ml
BSB 2535 Concentrated 1:50-1:200 0.5 ml
BSB 2536 Concentrated 1:50-1:200 1.0 ml
BSB 2537 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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