IHC of MCM3 on an FFPE Colon Carcinoma Tissue

IHC of MCM3 on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation MCM3 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication proteins. MCM3 is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progrsession.
Increased expression of MCM3 has been demonstrated in various tymors by immunohistochemistry and is used as a marker for tumor progression.
Antibody Type Rabbit Monoclonal Clone EP202
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Colon Carcinoma
Presentation MCM-3 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6884 Prediluted Ready-To-Use 3.0 ml
BSB 6885 Prediluted Ready-To-Use 7.0 ml
BSB 6886 Prediluted Ready-To-Use 15.0 ml
BSB 6887 Concentrated 1:25-1:100 0.1 ml
BSB 6888 Concentrated 1:25-1:100 0.5 ml
BSB 6889 Concentrated 1:25-1:100 1.0 ml
BSB 6890 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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