IHC of Maspin on an FFPE Breast Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

Maspin (mammary serine protease inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. This protein belongs to the serpin (serine protease inhibitor) superfamily. SERPINB5 was originally reported to function as a tumor suppressor gene in epithelial cells, suppressing the ability of cancer cells to invade and metastasize to other tissues.

Maspin has been shown in primary breast cancer to be regulated by wild-type p53, defining a new category of molecular targets of p53 that have the potential to negatively regulate tumor invasion and metastasis. Loss of Maspin expression correlates with increased tumor aggressiveness and poor prognosis in advanced breast and prostate cancer. In contrast, Maspin has been shown to be overexpressed in pancreatic, ovarian, thyroid, gastric, lung, bladder, breast, skin and colon cancer. Several studies have investigated the prognostic significance of Maspin expression in lung cancer. In primary non-small cell lung cancer (NSCLC) was an independent negative prognostic factor for overall survival, whereas strong nuclear Maspin expression was associated with increased overall and disease-free survival in patients with resectable NSCLC.

Antibody Type Mouse Monoclonal Clone BSB-92
Isotype IgG2a Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Prostate, Breast, Tonsil
Presentation Maspin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3265 Prediluted Ready-To-Use 3.0 ml
BSB 3266 Prediluted Ready-To-Use 7.0 ml
BSB 3267 Prediluted Ready-To-Use 15.0 ml
BSB 3268 Concentrated 1:25-1:100 0.1 ml
BSB 3269 Concentrated 1:25-1:100 0.5 ml
BSB 3270 Concentrated 1:25-1:100 1.0 ml
BSB 3271 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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