IHC of Macrophage on an FFPE Liver Tissue

IHC of Macrophage on an FFPE Liver Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Macrophages comprise many forms of mononuclear phagocytes found in tissues that derive from hematopoietic stem cells in the bone marrow. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, killing of ingested microorganisms, and digestion and presentation of antigens to T and B-lymphocytes. Macrophages work to secrete a large number of diverse products such as lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). Macrophage HAM-56 reacts with tingible macrophages (found in the germinal centers of lymph nodes), interdigitating macrophages of lymph nodes and tissue macrophages, (e.g., Kupffer cells of the liver and alveolar macrophages of the lung). This antibody also stains a subpopulation of endothelial cells, most prominently those of the capillaries and smaller blood vessels. HAM-56 reacts with monocytes, but is unreactive with B and T-lymphocytes.
Antibody Type Mouse Monoclonal Clone HAM-56
Isotype IgM/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node
Presentation Macrophage HAM-56 is a mouse monoclonal antibody derived from cell culture supernatant that isconcentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5736 Prediluted Ready-To-Use 3.0 ml
BSB 5737 Prediluted Ready-To-Use 7.0 ml
BSB 5738 Prediluted Ready-To-Use 15.0 ml
BSB 5739 Concentrated 1:250-1:1000 0.1 ml
BSB 5740 Concentrated 1:250-1:1000 0.5 ml
BSB 5741 Concentrated 1:250-1:1000 1.0 ml
BSB 5742 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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