IHC of Lysozyme on an FFPE Kidney Tissue

Specification Sheets
Safety Data Sheet
Intended UseFor In Vitro Diagnostic Use
Summary and ExplanationLysozyme is a 14.4 kDa enzyme, commonly referred to as the “body’s own antibiotic” since it kills bacteria. Lysozyme is an enzyme that destroys bacterial cell walls by hydrolyzing the polysaccharide component of the cell wall. It is abundantly present in a number of secretions, including tears. This protein is present in cytoplasmic granules of the polymorphonuclear neutrophils (PMN) and released through mucosal secretions such as tears and saliva. They can also be found in high concentration in egg white.
Lysozyme stains myeloid cells, histiocytes, granulocytes, macrophages, and monocytes in human tonsil, colon and skin. It is an important marker that may demonstrate the myeloid or monocytic nature of Acute Leukemia. The restrictive nature of Lysozyme antibody staining suggests that Lysozyme may be synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes. It has not been determined whether Lysozyme stains any other cell or tissue type. Lysozyme may aid in the identification of histiocytic neoplasias and large lymphocytes, as well as classifying lymphoproliferative disorders.
Antibody TypeRabbit MonoclonalCloneEP134
IsotypeIgGReactivityParaffin, Frozen
LocalizationCytoplasmicControlTonsil, Lymph Node, Liver, Kidney, Spleen, Salivary Gland, Cervix, Pancreas, Bone Marrow, Colon, Lung
PresentationLysozyme is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No.Antibody TypeDilutionVolume/QTY
BSB 6856PredilutedReady-To-Use3.0 ml
BSB 6857PredilutedReady-To-Use7.0 ml
BSB 6858PredilutedReady-To-Use15.0 ml
BSB 6859Concentrated1:100-1:5000.1 ml
BSB 6860Concentrated1:100-1:5000.5 ml
BSB 6861Concentrated1:100-1:5001.0 ml
BSB 6862Control Slides5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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