IHC of LI-Cadherin on an FFPE Colon Carcinoma Tissue

IHC of Li-Cadherin on an FFPE Colon Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation LI-Cadherin, also known as Cadherin-17, is part of the cadherin superfamily and is a calcium-dependent, membrane-associated glycoprotein. Cadherins are responsible for mediating cell-cell adhesion and are important for the structural integrity of epithelia. LI-Cadherin consists of an extracellular region containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. It is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. It may play a role in the morphological organization of liver and intestine.
In normal tissues, the LI-Cadherin antibody labels epithelial cells in the gastrointestinal tract and pancreatic duct, but not in kidney, liver and other tissues. In tumors, LI-Cadherin is expressed on adenocarcinoma of the digestive system, including liver cancer. It is a sensitve marker for the identification of gastric intestinal metaplasia and well differentiated adenocarcinomas.
Antibody Type Rabbit Monoclonal Clone EP86
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Colon
Presentation LI-Cadherin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6849 Prediluted Ready-To-Use 3.0 ml
BSB 6850 Prediluted Ready-To-Use 7.0 ml
BSB 6851 Prediluted Ready-To-Use 15.0 ml
BSB 6852 Concentrated 1:25-1:100 0.1 ml
BSB 6853 Concentrated 1:25-1:100 0.5 ml
BSB 6854 Concentrated 1:25-1:100 1.0 ml
BSB 6855 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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