IHC of Langerin on an FFPE Skin Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Langerin is a type II transmembrane cell surface receptor produced by Langerhans Cells, which are immature dendritic cells of the epidermis and mucosa. Epidermal LCs possess strong immunohistochemistry capacity and play a central role in the initiation and regulation of immune responses. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and provides access to a nonclassical antigen-processing pathway.
Human spleen, lymph node, thymus, liver, lung, and heart express langerin protein. Langerin protein expression has utility in differentiating Langerhans cell histiocytosis from other non- Langerhans cell histiocytic proliferations.
|Antibody Type||Mouse Monoclonal||Clone||12D6|
|Localization||Cytoplasmic||Control||Skin, Breast, Prostate, Cervix, Liver, salivary Gland, Langerahns Histiocytosis|
|Presentation||Langerin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|