IHC of Langerin on an FFPE Skin Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation Langerin is a type II transmembrane cell surface receptor produced by Langerhans Cells, which are immature dendritic cells of the epidermis and mucosa. Epidermal LCs possess strong immunohistochemistry capacity and play a central role in the initiation and regulation of immune responses. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and provides access to a nonclassical antigen-processing pathway.
Human spleen, lymph node, thymus, liver, lung, and heart express langerin protein. Langerin protein expression has utility in differentiating Langerhans cell histiocytosis from other non- Langerhans cell histiocytic proliferations.
Antibody Type Mouse Monoclonal Clone 12D6
Isotype IgG2b/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Skin, Breast, Prostate, Cervix, Liver, salivary Gland, Langerahns Histiocytosis
Presentation Langerin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6842 Prediluted Ready-To-Use 3.0 ml
BSB 6843 Prediluted Ready-To-Use 7.0 ml
BSB 6844 Prediluted Ready-To-Use 15.0 ml
BSB 6845 Concentrated 1:50-1:200 0.1 ml
BSB 6846 Concentrated 1:50-1:200 0.5 ml
BSB 6847 Concentrated 1:50-1:200 1.0 ml
BSB 6848 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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