IHC of Ki-67 on an FFPE HSIL of the Cervix

IHC of Ki-67 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation The Ki-67 protein is a cellular marker for proliferation. It is strictly associated with cell proliferation. During the interphase, the Ki-67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. Ki-67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0). Ki-67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. The best-studied examples in this context are Carcinomas of the Prostate and the Breast.
Antibody Type Rabbit Monoclonal Clone EP5
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Testis, Tonsil, Bone Marrow, Placenta, colon, Tonsil, Fallopian tube, Astrocytoma, Breast Carcinoma, Colon Carcinoma
Presentation Ki-67 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5708 Prediluted Ready-To-Use 3.0 ml
BSB 5709 Prediluted Ready-To-Use 7.0 ml
BSB 5710 Prediluted Ready-To-Use 15.0 ml
BSB 5711 Concentrated 1:25-1:100 0.1 ml
BSB 5712 Concentrated 1:25-1:100 0.5 ml
BSB 5713 Concentrated 1:25-1:100 1.0 ml
BSB 5714 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
* The Ki-67 antibody, clone EP5, has been manufactured using Epitomics RabMab® technology covered under Patent No.’s 5,675,063 and 7,402,409.
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