IHC of Kappa on an FFPE Tonsil Tissue

IHC of Kappa on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, Kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulin. When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a kappa-lambda ratio greater than or equal to 3:1, a lambda-kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population.
Antibody Type Mouse Monoclonal Clone BSB-58
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node
Presentation Kappa is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5701 Prediluted Ready-To-Use 3.0 ml
BSB 5702 Prediluted Ready-To-Use 7.0 ml
BSB 5703 Prediluted Ready-To-Use 15.0 ml
BSB 5704 Concentrated 1:250-1:1000 0.1 ml
BSB 5705 Concentrated 1:250-1:1000 0.5 ml
BSB 5706 Concentrated 1:250-1:1000 1.0 ml
BSB 5707 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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