IHC of Islet 1 on an FFPE Pancreas Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

Islet-1, Insulin gene enhancer protein ISL-1, is a protein that in humans is encoded by the ISL1 gene. This gene encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeo domain. The encoded protein plays an important role in the embryogenesis of pancreatic islets of Langerhans. ISL1 has been shown to interact with Estrogen Receptor alpha.

Islet-1 produces a strong nuclear staining in the islets of normal pancreas and tumor cells of the pancreatic neuroendocrine tumors. Islet-1 has been found to be a reliable marker of pancreatic endocrine tumors and metastasis. It shows a comparable sensitivity and specificity as CDX2 as a marker of ileal and appendiceal neuroendocrine tumors and their metastasis. TTF1 is very rarely expressed in well-differentiated gastroentero-pancreatic endocrine tumors. Therefore, the panel of Islet-1 CDX2, and TTF1 and they may be useful for examining metastasis of well-differentiated endocrine carcinomas of unknown origin.

Antibody Type Rabbit Monoclonal Clone EP283
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Pancreas, Testis, Thyroid, Cervix, Skin, Pancreatic Neuroendocrine Cancer
Presentation Islet 1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2971 Prediluted Ready-To-Use 3.0 ml
BSB 2972 Prediluted Ready-To-Use 7.0 ml
BSB 2973 Prediluted Ready-To-Use 15.0 ml
BSB 2974 Concentrated 1:25-1:100 0.1 ml
BSB 2975 Concentrated 1:25-1:100 0.5 ml
BSB 2976 Concentrated 1:25-1:100 1.0 ml
BSB 2977 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
Related Products