IHC of MMP-9 on an FFPE Lymphomblastic Lymphoma Tissue

IHC of MMP-9 on an FFPE Lymphoblastic Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation
The matrix metalloproteinases (MMPs) are responsible for degradation of the extracellular matrix. The MMPs and their specific tissue inhibitor metalloproteinases (TIMP) have been associated with tumor cell invasion and metastasis in a number of adult tumors. MMP-9, also designated as 92-kDa Type IV Collagenase or gelatinase B, is a member of MMPs, which is produced as a 92- kDa pro-enzyme by neutrophils, macrophages, mast cells and stromal cells, as a normal constituent and released into the extracellular environment after activation in inflammatory tissues.
MMP-9 may be involved in the development of several human malignancies, as degradation of collagen IV in basement membrane and extracellular matrix facilitates tumor progression, including invasion, metastasis, growth and angiogenesis. The expression levels of MMP-9 in tumors are elevated compared with the corresponding normal tissues in a variety of cancer types, including breast, colon, gastric and nasopharyngeal cancers. MMP-9 may play an important role in angiogenesis and neovascularization. For example, MMP9 appears to be involved
in the remodeling associated with malignant glioma neovascularization. Increased expression has been seen in a metastatic mammary cancer cell line.
Antibody Type Rabbitt Monoclonal Clone EP-127
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control
Tonsil, Spleen, Lymphoblastic Lymphoma
Presentation
MMP-9 is a rabbit monoclonal antibody derived from cell culture supernatant thatis concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2538 Prediluted Ready-To-Use 3.0 ml
BSB 2539 Prediluted Ready-To-Use 7.0 ml
BSB 2540 Prediluted Ready-To-Use 15.0 ml
BSB 2541 Concentrated 1:50-1:200 0.1 ml
BSB 2542 Concentrated 1:50-1:200 0.5 ml
BSB 2543 Concentrated 1:50-1:200 1.0 ml
BSB 2544 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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