IHC of INI-1 on an FFPE Ewing’s Sarcoma Tissue

IHC of INI-1 on an FFPE Ewing’s Sarcoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/ SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing.
The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratenorial primitive neuroectodermal tumors (sPNETs)) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
Antibody Type Mouse Monoclonal Clone 25
Isotype IgG2a Reactivity Paraffin, Frozen
Localization Nuclear Control Testis, Brain, Breast, Colon, Kidney, Pituitary, Adrenal, Prostate, Thyroid, Lung, Pancreas, Cervix, Salivary Gland, Astrocytoma, Lymphoblastic Lymphoma, Transitional Cell Carcinoma
Presentation INI-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6828 Prediluted Ready-To-Use 3.0 ml
BSB 6829 Prediluted Ready-To-Use 7.0 ml
BSB 6830 Prediluted Ready-To-Use 15.0 ml
BSB 6831 Concentrated 1:25-1:100 0.1 ml
BSB 6832 Concentrated 1:25-1:100 0.5 ml
BSB 6833 Concentrated 1:25-1:100 1.0 ml
BSB 6834 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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