IHC of IgM on an FFPE Axilar Lymph Node with Metastatic Breast Carcinoma

IHC of IgM on an FFPE Axilar Lymph Node with Metastatic Breast Carcinoma

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, normally as a pentamer or occasionally as a hexamer. It has a large molecular mass of approximately 900 kDa (in its pentamer form). In germline cells, the gene segment encoding the constant region of the heavy chain is positioned first among other constant region gene segments. For this reason, IgM is the first immunoglobulin expressed by mature B-cells. IgM antibody reacts with surface immunoglobulin IgM mu chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes, and is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.
Antibody Type Mouse Monoclonal Clone BSB-41
Isotype IgG1/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node, Spleen, Kidney, Colon
Presentation IgM is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5680 Prediluted Ready-To-Use 3.0 ml
BSB 5681 Prediluted Ready-To-Use 7.0 ml
BSB 5682 Prediluted Ready-To-Use 15.0 ml
BSB 5683 Concentrated 1:100-1:500 0.1 ml
BSB 5684 Concentrated 1:100-1:500 0.5 ml
BSB 5685 Concentrated 1:100-1:500 1.0 ml
BSB 5686 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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