IHC of IgG4 on an FFPE Tonsil Tissue

IHC of IgG4 on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. As these patients tend to respond favorably to steroid treatment, it is important to recognize this entity and differentiate it from such mimics as lymphoma.
Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibits significantly more IgG4- positive plasma cells in affected tissues but also significantly higher IgG4/ IgG ratios (typically 30%).
Antibody Type Rabbit Monoclonal Clone EP138
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Colon, Tonsil, Spleen
Presentation IgG4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6814 Prediluted Ready-To-Use 3.0 ml
BSB 6815 Prediluted Ready-To-Use 7.0 ml
BSB 6816 Prediluted Ready-To-Use 15.0 ml
BSB 6817 Concentrated 1:50-1:200 0.1 ml
BSB 6818 Concentrated 1:50-1:200 0.5 ml
BSB 6819 Concentrated 1:50-1:200 1.0 ml
BSB 6820 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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