IHC of IgG on an FFPE Tonsil Tissue

IHC of IgG on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation IgG is a monomeric immunoglobulin, built of two heavy chains and two light chains. This is the most abundant immunoglobulin and is approximately equally distributed in blood and tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the placenta and bind to many kinds of pathogens. IgG protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralization of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). IgG antibody reacts with surface immunoglobulin IgG gamma chains. This antibody is useful when identifying Leukemias, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. Due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies.
Antibody Type Mouse Monoclonal Clone BSB-40
Isotype IgG2a/K Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node, Kidney, Spleen
Presentation IgG antibody is the purified immunoglobulin fraction of rabbit antiserum, diluted in Phosphate Buffered Saline, pH 7.6, with protein base, and preserved with Sodium Azide preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5673 Prediluted Ready-To-Use 3.0 ml
BSB 5674 Prediluted Ready-To-Use 7.0 ml
BSB 5675 Prediluted Ready-To-Use 15.0 ml
BSB 5676 Concentrated 1:250-1:1000 0.1 ml
BSB 5677 Concentrated 1:250-1:1000 0.5 ml
BSB 5678 Concentrated 1:250-1:1000 1.0 ml
BSB 5679 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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