IHC of IgA on a FFPE Kidney Tissue

IF of IgA on a Frozen Bullous Dermatosis Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.

This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.

Summary and Explanation Immunoglobulin A (IgA) is the main immunoglobulin in mucous secretions, including tears, saliva, and colostrum, as well as respiratory, intestinal, prostatic, and vaginal secretions. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes, secretory IgA provides protection against microbes proliferating in body secretions, especially those of the digestive and respiratory tracts.

IgA antibody reacts with surface immunoglobulin IgA alpha chains. It is extremely useful when identifying Acute Leukemias, IgA Myelomas, Plasmacytomas, and B-cell lineage derived Hodgkin’s Lymphomas. However, due to the restricted expression of heavy and light chains in these diseases, demonstration of B-cell Lymphomas is possible with clonal gene-rearrangement studies. Lupus nephritis is an inflammation of the kidneys caused by Systemic Lupus Erythematosus. Immunofluorescence reveals positively for IgG, IgA, IgM, C3, and C1q.

Antibody Type Rabbit Polyclonal Clone Polyclonal
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Spleen, Lymph Node, Kidney, Colon
Presentation IgA is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3054 Prediluted Ready-To-Use* 3.0 ml
BSB 3055 Prediluted Ready-To-Use* 7.0 ml
BSB 3056 Prediluted Ready-To-Use* 15.0 ml
BSB 3057 Concentrated 1:500 / 1:10 0.1 ml
BSB 3058 Concentrated 1:500 / 1:10 0.5 ml
BSB 3059 Concentrated 1:500 / 1:10 1.0 ml
BSB 3685 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

*Ready-to-Use, for IHC only!