IHC of HLA-DRB1 beta chain on an FFPE Tonsil Tissue

IHC of HLA-DRB1 beta chain on an FFPE Tonsil Tissue

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Research Use
Safety Data Sheet

SDS

Control Slides
Intended Use For In Vitro Diagnostic Use
Summary and Explanation HLA class II histocompatibility antigen, DRB1-9 beta chain belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. HLA-DRB1 is expressed mainly on antigen-presenting cells, such as B lymphocytes, monyctes and dendritic cells, but can also be detected on activated T lymphocytes and activated granulocytes.
In abnormal tissues, HLA-DRB1 has been found in different types of Acute Lymphoblastic Leukemias and Acute Myeloid Leukemias. Additionally, HDLADR was also found in some nonhematopoietic tumors, including carcinomas of the colon and breast.
Antibody Type Rabbit Monoclonal Clone EP191
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Spleen
Presentation HLA-DRB1 Beta Chain is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2433 Prediluted Ready-To-Use 3.0 ml
BSB 2434 Prediluted Ready-To-Use 7.0 ml
BSB 2435 Prediluted Ready-To-Use 15.0 ml
BSB 2436 Concentrated 1:25-1:100 0.1 ml
BSB 2437 Concentrated 1:25-1:100 0.5 ml
BSB 2438 Concentrated 1:25-1:100 1.0 ml
BSB 2439 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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