IHC of Histone H3 Phospho on an FFPE Breast Carcinoma Tissue

IHC of Histone H3 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Phosphohistone-H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucelosomes of the “beads on a string” structure. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis.
Phosphohistone-H3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, Gyn., soft tissue, and GIST.
Antibody Type Rabbit Polyclonal Clone Polyclonal
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Tonsil, Lymph Node
Presentation Histone H3 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6821 Prediluted Ready-To-Use 3.0 ml
BSB 6822 Prediluted Ready-To-Use 7.0 ml
BSB 6823 Prediluted Ready-To-Use 15.0 ml
BSB 6824 Concentrated 1:25-1:100 0.1 ml
BSB 6825 Concentrated 1:25-1:100 0.5 ml
BSB 6826 Concentrated 1:25-1:100 1.0 ml
BSB 6827 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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