IHC of Histone H3 Phospho on an FFPE NH Lymphoma Tissue

IHC of Histone H3 Phospho on an FFPE NH Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation
Phosphohistone-H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucelosomes of the “beads on a string” structure. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis.
Phosphohistone-H3 can serve as a mitotic marker to separate mitotic figures fromapoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, Gyn., soft tissue, and GIST.
Antibody Type Rabbitt Monoclonal Clone EP233
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control
Tonsil, Lymph Node
Presentation
Histone H3 Phospho is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2524 Prediluted Ready-To-Use 3.0 ml
BSB 2525 Prediluted Ready-To-Use 7.0 ml
BSB 2526 Prediluted Ready-To-Use 15.0 ml
BSB 2527 Concentrated 1:100-1:500 0.1 ml
BSB 2528 Concentrated 1:100-1:500 0.5 ml
BSB 2529 Concentrated 1:100-1:500 1.0 ml
BSB 2530 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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