HC of HER-3 on an FFPE Colon Tissue

IHC of HER-3 on an FFPE Colon Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.
Summary and Explanation Receptor tyrosine-protein kinase erbB-3, also known as HER-3 (Human Epidermal Growth Factor Receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. HER-3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. HER-3 can heterodimerize with any of the other three ErbB family members.
During human development, HER-3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium and is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. HER-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. While no evidence has been found that HER-3 overexpression, constitutive activation, or mutation alone is oncogenic, the protein as a heterodimerization partner, most critically with HER-2, is implicated in growth, proliferation, resistance, and the promotion of invasion and metastasis.
Antibody Type Rabbit Monoclonal Clone RBT-HER3
Isotype IgG Reactivity Paraffin, Frozen
Localization Membranous Control
Colon, Cervix, Bladder TCC
Presentation HER-3 is a rabbit monoclonal antibody derived from cell culture supernatant thatis concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2629 Prediluted Ready-To-Use 3.0 ml
BSB 2630 Prediluted Ready-To-Use 7.0 ml
BSB 2631 Prediluted Ready-To-Use 15.0 ml
BSB 2632 Concentrated 1:25-1:100 0.1 ml
BSB 2633 Concentrated 1:25-1:100 0.5 ml
BSB 2634 Concentrated 1:25-1:100 1.0 ml
BSB 2635 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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