IHC of HER-2 neu Phospho RMab on an FFPE Breast Carcinoma Tissue

IHC of HER-2 neu Phospho RMab on an FFPE Breast Carcinoma Tissue

United States
International
Research Use
Safety Data Sheet

SDS

Control Slides
Intended Use For Analyte Specific Reagent
Summary and Explanation HER2 / ErbB2 is one of four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases .The kinase activity of ErbB2 can be activated without a ligand if it is overexpressed, and by association with other ErbB proteins. Autophosphorylation did not modulate receptor turnover. A Tyr–Phe substitution of ErbB2 Tyr-877 homologous to pp60c-src Tyr-416 did not alter ErbB2 biological and biochemical properties, thus excluding the possibility that phosphorylation of this residue, located in the kinase domain, modulates ErbB2 gp185 catalytic function.
HER2 is overexpressed in 25–30% of all breast cancers, including primary as well as metastatic breast tumors. HER2 has been widely investigated as a prognostic indicator. Detection of phosphorylated HER2 may aid in predicting breast cancer progression.
Antibody Type Rabbit Monoclonal Clone EP123
Isotype IgG Reactivity Paraffin, Frozen
Localization Membranous Control Breast Carcinoma
Presentation HER-2 neu phospho is a rabbit monoclonal antibody derived from cell culture
supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer
pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2503 Prediluted Ready-To-Use 3.0 ml
BSB 2504 Prediluted Ready-To-Use 7.0 ml
BSB 2505 Prediluted Ready-To-Use 15.0 ml
BSB 2506 Concentrated 1:100-1:500 0.1 ml
BSB 2507 Concentrated 1:100-1:500 0.5 ml
BSB 2508 Concentrated 1:100-1:500 1.0 ml
BSB 2509 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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