IHC of Hemaglobin A on an FFPE Placenta Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Hemoglobin alpha chain belongs to the globin family and is involved in oxygen transport from the lung to various peripheral tissues. It is a heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA); two alpha chains and two delta chains in adult hemoglobin A2 (HbA2). Hemoglobin alpha chain is expressed in red blood cells, and defects in HBA1/HBA2 can lead to alpha thalassemia, the most common of monogenic diseases.
Hemoglobin alpha chain is a useful marker for erythroid cells. An antibody to Hemoglobin alpha has been used for the identification of erythroid cells in myeloproliferative disease.
|Antibody Type||Rabbit Monoclonal||Clone||EP124|
|Localization||Cytoplasmic||Control||Spleen, Bone Marrow, Placenta|
|Presentation||Hemoglobin A is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|