IHC of Granzyme B on an FFPE Spleen Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Granzymes are exogenous serine proteases that are released by cytoplasmic granules within cytotoxic T-cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them.
Anti-Granzyme B antibodies have been useful in diagnosing Natural Killer/T-cell Lymphoma, as well as Anaplastic Large Cell Lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin’s Disease.
Antibody Type Rabbit Monoclonal Clone EP230
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic (Granular) Control Liver, Testis, Cervix, Tonsil, Lymph Node, Spleen
Presentation Granzyme B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2405 Prediluted Ready-To-Use 3.0 ml
BSB 2406 Prediluted Ready-To-Use 7.0 ml
BSB 2407 Prediluted Ready-To-Use 15.0 ml
BSB 2408 Concentrated 1:25-1:100 0.1 ml
BSB 2409 Concentrated 1:25-1:100 0.5 ml
BSB 2410 Concentrated 1:25-1:100 1.0 ml
BSB 2411 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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