IHC of Granzyme B on an FFPE Spleen Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Granzymes are exogenous serine proteases that are released by cytoplasmic granules within cytotoxic T-cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them.
Anti-Granzyme B antibodies have been useful in diagnosing Natural Killer/T-cell Lymphoma, as well as Anaplastic Large Cell Lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin’s Disease.
|Antibody Type||Rabbit Monoclonal||Clone||EP230|
|Localization||Cytoplasmic (Granular)||Control||Liver, Testis, Cervix, Tonsil, Lymph Node, Spleen|
|Presentation||Granzyme B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|