IHC of Glucagon on an FFPE Pancreas Tissue

IHC of Glucagon on an FFPE Pancreas Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Glucagon is a 29-amino acid polypeptide acting as an important hormone in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Abnormally-elevated levels of glucagon may be caused by pancreatic tumors such as glucagonoma, symptoms of which include necrolytic migratory erythema (NME), elevated amino acids and hyperglycemia. It may occur alone or in the context of Multiple Endocrine Neoplasia Type 1. Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas. Studies show that approximately 80% of glucagonomas are malignant and these patients have a syndrome most often initially recognized by dermatologists. Symptoms include necrolytic migratory erythema as well as diabetes, anemia, stomatitis, weight loss, frequent venous thromboses, and in some instances, diarrhea and psychiatric disturbances. The diagnosis may be readily confirmed by the demonstration of elevated plasma glucagon concentration.
Antibody Type Rabbit Monoclonal Clone EP74
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Colon, Pancreas
Presentation Anti-Glucagon is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized an diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2328 Tinto Prediluted Ready-To-Use 3.0 ml
BSB 2329 Tinto Prediluted Ready-To-Use 7.0 ml
BSB 2330 Tinto Prediluted Ready-To-Use 15.0 ml
BSB 2331 Concentrated 1:50-1:200 0.1 ml
BSB 2332 Concentrated 1:50-1:200 0.5 ml
BSB 2333 Concentrated 1:50-1:200 1.0 ml
BSB 2334 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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