IHC of Glucagon on an FFPE Pancreas Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Glucagon is a 29-amino acid polypeptide acting as an important hormone in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Abnormally-elevated levels of glucagon may be caused by pancreatic tumors such as glucagonoma, symptoms of which include necrolytic migratory erythema (NME), elevated amino acids and hyperglycemia. It may occur alone or in the context of Multiple Endocrine Neoplasia Type 1. Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas. Studies show that approximately 80% of glucagonomas are malignant and these patients have a syndrome most often initially recognized by dermatologists. Symptoms include necrolytic migratory erythema as well as diabetes, anemia, stomatitis, weight loss, frequent venous thromboses, and in some instances, diarrhea and psychiatric disturbances. The diagnosis may be readily confirmed by the demonstration of elevated plasma glucagon concentration.
Antibody Type Rabbit Polyclonal Clone N/A
Isotype N/A Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Colon, Pancreas
Presentation Glucagon is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5575 Tinto Prediluted Ready-To-Use 3.0 ml
BSB 5576 Tinto Prediluted Ready-To-Use 7.0 ml
BSB 5577 Tinto Prediluted Ready-To-Use 15.0 ml
BSB 5578 Concentrated 1:50-1:200 0.1 ml
BSB 5579 Concentrated 1:50-1:200 0.5 ml
BSB 5580 Concentrated 1:50-1:200 1.0 ml
BSB 5581 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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