IHC of GCDFP-15 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Gross Cystic Disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross Cystic Disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15 kDa monomer protein, GCDFP-15. The cells within the body that produce GCDFP-15 appear to be restricted primarily to those with apocrine function such as breast cysts and in apocrine glands in the axilla, vulva, eyelid, and ear canal. Studies have found GCDFP-15 to be a highly specific and sensitive marker for breast cancer. Approximately 70% of breast carcinomas stain positive with antibody to GCDFP-15. In contrast, Colorectal Carcinomas, as well as Mesotheliomas, do not stain with this antibody. Lung Adenocarcinomas rarely stain with this antibody.
Antibody Type Mouse Monoclonal Clone 23A3
Isotype IgG2a Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Breast, Salivary Gland, Breast Carcinoma, Sweat Glands in Skin
Presentation GCDFP-15 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5554 Prediluted Ready-To-Use 3.0 ml
BSB 5555 Prediluted Ready-To-Use 7.0 ml
BSB 5556 Prediluted Ready-To-Use 15.0 ml
BSB 5557 Concentrated 1:100-1:500 0.1 ml
BSB 5558 Concentrated 1:100-1:500 0.5 ml
BSB 5559 Concentrated 1:100-1:500 1.0 ml
BSB 5560 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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