HC of GATA-3 on an FFPE Breast Carcinoma Tissue

IHC of GATA-3 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
 
Summary and Explanation Trans-acting T-cell-specific transcription factor, GATA-3 is, a protein that in humans is encoded by the GATA3 gene. GATA-3 b regulates luminal epithelial cell differentiation in the mammary gland, is an important regulator of T cell development and plays an important role in endothelial cell biology.GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong predictor of taxane and platin salts insensitivity.GATA3 expression is found in urothelial carcinoma, especially in invasive and high grade tumors. Therefore, anti-GATA3 can be used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are a possibility. Studies have also shown the utility of GATA-3 in differntiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine, cervix, anus and lung.
  Antibody Type Mouse Monoclonal Clone L50-823
  Isotype IgG1/K Reactivity Paraffin, Frozen
  Localization Nuclear Control Breast Carcinoma
 
Presentation GATA3 clone L50-823 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
 
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2670 Prediluted Ready-To-Use 3.0 ml
BSB 2671 Prediluted Ready-To-Use 7.0 ml
BSB 2672 Prediluted Ready-To-Use 15.0 ml
BSB 2673 Concentrated 1:50-1:200 0.1 ml
BSB 2674 Concentrated 1:50-1:200 0.5 ml
BSB 2675 Concentrated 1:50-1:200 1.0 ml
BSB 2676 Control Slides  N/A 5 slides
  Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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