IHC of FOXP3 on an FFPE Thymus Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

FOXP3, also known as scurfin, is a protein involved in immune system responses. A member of the forkhead box protein family, FOXP3 appears to function as a transcription factor in the development and function of regulatory T cells. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters of many important for regulatory T-cell function, and may repress transcription of key genes following stimulation of T cell receptors.

Alterations in numbers of regulatory T-cells – in particular those that express FOXP3 – are found in a number of disease states. Patients with tumors have a local relative excess of FOXP3 positive T cells which inhibits the body’s ability to suppress the formation of cancerous cells.

Antibody Type Rabbit Monoclonal Clone EP340
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear Control Tonsil, Lymph Node, Thymus
Presentation FOXP3 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2922 Prediluted Ready-To-Use 3.0 ml
BSB 2923 Prediluted Ready-To-Use 7.0 ml
BSB 2924 Prediluted Ready-To-Use 15.0 ml
BSB 2925 Concentrated 1:25-1:100 0.1 ml
BSB 2926 Concentrated 1:25-1:100 0.5 ml
BSB 2927 Concentrated 1:25-1:100 1.0 ml
BSB 2928 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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