IHC of FOXA1 on an FFPE Breast Carcinoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. FOXA1 is a downstream target of GATA3 in the mammary gland.
FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 absence in ERα+ cancer might identify ERa cancers that are resistant to endocrine therapy. In ERα− breast cancer, FOXA1 is highly correlated with improved disease free survival and GATA3. Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.
Antibody Type Rabbit Polyclonal Clone Polyclonal
Isotype IgG Reactivity Paraffin, Frozen
Localization Nuclear, Cytoplasmic Control Breast, Prostate, Tonsil, Breast Carcinoma, Prostate Carcinoma, Bladder TCC
Presentation FOXA1 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6744 Prediluted Ready-To-Use 3.0 ml
BSB 6745 Prediluted Ready-To-Use 7.0 ml
BSB 6746 Prediluted Ready-To-Use 15.0 ml
BSB 6747 Concentrated 1:25-1:100 0.1 ml
BSB 6748 Concentrated 1:25-1:100 0.5 ml
BSB 6749 Concentrated 1:25-1:100 1.0 ml
BSB 6750 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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