IHC of Fibrinogen on a FFPE Kidney Tissue

IF of Fibrinogen on a Frozen Lichen Planus Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use.

This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.

Summary and Explanation Fibrinogen (factor I) is a glycoprotein that circulates in the blood of vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and subsequently to a fibrin-based blood clot. Fibrinogen functions primarily to occlude blood vessels and thereby stop excessive bleeding. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby functions to promote tissue revascularization, wound healing, and tissue repair.

Several disorders (Congenital afibrinogenemia, hypofibrinogenemia, Fibrinogen storage disease, Hereditary fibrinogen Aα-Chain amyloidosis, Congenital hypodysfibrinogenemia, Cryofibrinogenemia, acquired hypofibrinogenemia, Chronic Kidney Disease, etc.) in the quantity and/or quality of fibrinogen cause pathological bleeding, pathological blood clotting, and/or the deposition of fibrinogen in the liver, kidneys, and other tissues. Chronic kidney disease (CKD) patients have increased rates of bleeding as well as thrombosis. Fibrinogen and platelets combine to generate a mature clot, but in CKD platelets are dysfunctional.

Antibody Type Rabbit Polyclonal Clone Polyclonal
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Breast, Testis, Kidney, Pancreas, Salivary Gland, Skin Fallopian Tube
Presentation Fibrinogen is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 3047 Prediluted Ready-To-Use* 3.0 ml
BSB 3048 Prediluted Ready-To-Use* 7.0 ml
BSB 3049 Prediluted Ready-To-Use* 15.0 ml
BSB 3050 Concentrated 1:50 / 1:10 0.1 ml
BSB 3051 Concentrated 1:50 / 1:10 0.5 ml
BSB 3052 Concentrated 1:50 / 1:10 1.0 ml
BSB 3053 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

*Ready-to-Use, for IHC only!