IHC of Factor XIIIa on an FFPE Placenta Tissue

IHC of Factor XIIIa on an FFPE Placenta Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Factor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into Factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells present in the placenta, uterus, and prostate; it is also present in monocytes, macrophages and dermal dendritic cells. Anti-Factor XIIIa has been found to be useful in differentiating between Dermatofibroma (90% (+)), Dermatofibrosarcoma Protuberans (25%(+)) and Desmoplastic Malignant Melanoma (0%(+)). Factor XIIIa positivity is also seen in Capillary Hemagioblastoma (100%(+)), Hemangioendothelioma (100%(+)), Hemangiopericytoma (100%(+)), Xanthogranuloma (100%(+)), Xanthoma (100(+)), Hepatocellular Carcinoma (93%(+)), Glomus Tumor (80%(+)), and Meningioma 80%(+)).
Antibody Type Rabbit Monoclonal Clone EP292
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Placenta, Testis, Tonsil, Skin, Colon
Presentation Anti-Factor XIIIa is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5505 Prediluted Ready-To-Use 3.0 ml
BSB 5506 Prediluted Ready-To-Use 7.0 ml
BSB 5507 Prediluted Ready-To-Use 15.0 ml
BSB 5508 Concentrated 1:50-1:200 0.1 ml
BSB 5509 Concentrated 1:50-1:200 0.5 ml
BSB 5510 Concentrated 1:50-1:200 1.0 ml
BSB 5511 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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