IHC of Factor VIII on an FFPE Placenta Tissue

IHC of Factor VIII on an FFPE Placenta Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Factor VIII (F VIII) is an essential clotting factor. The lack of normal F VIII causes Hemophilia A, an inherited bleeding disorder. FVIII is a glycoprotein procofactor synthesized and released into the bloodstream by the liver. In the circulating blood, it is mainly bound to von Willebrand factor (vWF, also known as Factor VIII-related antigen) to form a stable complex. Upon activation by thrombin or Factor Xa, it dissociates from the complex to interact with Factor IXa, the coagulation cascade. It is a cofactor to Factor IXa in the activation of Factor X, which, in turn, with its cofactor Factor Va, activates more thrombin. Thrombin cleaves fibrinogen into fibrin which polymerizes and crosslinks (using Factor XIII) into a blood clot. This antibody reacts with endothelial cells in normal, reactive, and neoplastic blood cells. F VIII antibody has helped to establish the endothelial nature of some lesions of disputed histogenesis, e.g., Kaposi`s Sarcoma and Cardiac Myxoma. Not all endothelial cells synthesize (or store) this molecule; therefore, it should not be surprising that not all tumors of endothelial differentiation (benign or malignant) react with this antigen.
Antibody Type Rabbit Polyclonal Clone N/A
Isotype N/A Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Skin, Placenta
Presentation Factor VIII antibody is a purified immunoglobulin fraction of rabbit antiserum, diluted in phosphate buffered saline, pH 7.6, with protein, and preserved with sodium azide.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5498 Prediluted Ready-To-Use 3.0 ml
BSB 5499 Prediluted Ready-To-Use 7.0 ml
BSB 5500 Prediluted Ready-To-Use 15.0 ml
BSB 5501 Concentrated 1:50-1:200 0.1 ml
BSB 5502 Concentrated 1:50-1:200 0.5 ml
BSB 5503 Concentrated 1:50-1:200 1.0 ml
BSB 5504 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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