IHC of ERCC1 on an FFPE Lymphoblastic Lymphoma Tissue

IHC of ERCC1 on an FFPE Lymphoblastic Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
 
Summary and Explanation
excision repair protein ERCC1 is encoded by the ERCC1 gene on chromosome 19.Excision Repair Cross Complementing 1 (ERCC1) is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair.ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.Increased levels of ERCC1 expression may correlate with a lower response to platinum based chemotherapies. Studies have also showed however, that In non-small cell lung carcinoma (NSCLC), surgically removed tumors that receive no further therapy have a better survival if ERCC1-positive than if ERCC1-negative.
Antibody Type Rabbit Monoclonal Clone EP219
  Isotype IgG Reactivity Paraffin, Frozen
  Localization Nuclear Control Tonsil, Testis, Breast, Prostate, Fallopian Tube, Ovarian Carcinoma, Breast Carcinoma
 
Presentation ERCC1 s a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, fi lter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
 
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2482
Prediluted Ready-To-Use 3.0 ml
BSB 2483
Prediluted Ready-To-Use 7.0 ml
BSB 2484
Prediluted Ready-To-Use 15.0 ml
BSB 2485
Concentrated 1:50-1:200 0.1 ml
BSB 2486
Concentrated 1:50-1:200 0.5 ml
BSB 2487
Concentrated 1:50-1:200 1.0 ml
BSB 2488
Control Slides   5
  Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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