IHC of EMA on an FFPE Ovarian Adenocarcinoma Tissue

Specification Sheets
Safety Data Sheet


Intended Use For In Vitro Diagnostic Use
Summary and Explanation Epithelial Membrane Antigen (EMA) antibody is a mucin-like glycoprotein, shown to be useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in the bone marrow or liver. It stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium. Hepatocellular Carcinoma, Adrenal Carcinoma and Embryonal Carcinomas are consistently EMA negative, so keratin positivity with negative EMA favors one of these tumors. EMA is frequently positive in meningioma, which can be useful when distinguishing it from other intracranial neoplasms. The absence of EMA can also be of value since negative EMA is characteristic of some tumors including Adrenal Carcinoma, Seminomas, Paraganglioma and Hepatoma.
Antibody Type Mouse Monoclonal Clone E29
Isotype IgG2a/K Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Breast, Skin, Colon, Kidney, Cervix
Presentation EMA is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5477 Prediluted Ready-To-Use 3.0 ml
BSB 5478 Prediluted Ready-To-Use 7.0 ml
BSB 5479 Prediluted Ready-To-Use 15.0 ml
BSB 5480 Concentrated 1:500-1:2000 0.1 ml
BSB 5481 Concentrated 1:250-1:1000 0.5 ml
BSB 5482 Concentrated 1:250-1:1000 1.0 ml
BSB 5483 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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