IHC of Desmoglein 3 on an FFPE Anal Carcinoma

IHC of Desmoglein 3 on an FFPE Anal Carcinoma

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation
Desmoglein 3 is a protein that is encoded by the DSG3 gene on Chromosome 18. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
 
Desmoglein 3 has been cited as a superior marker for Lung Squamous Cell Carcinomas, and helps distinguish lung squamous cell carcinoma cases from lung adenocarcinoma.  Studies have also shown that a panel consisiting of Desmoglein-3 utilized with Napsin A can be a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes. Lung cases that are typically positive for Desmoglein 3 tend to have a poor clinical outcome.
Antibody Type Mouse Monoclonal Clone BSB-61
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Membranous Control Tonsil, Prostate, Skin, Cervix, Cervical Carcinoma, Lung Squamous Cell Carcinoma
Presentation Desmoglein 3 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, fi lter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2789 Prediluted Ready-To-Use 3.0 ml
BSB 2790 Prediluted Ready-To-Use 7.0 ml
BSB 2791 Prediluted Ready-To-Use 15.0 ml
BSB 2792 Concentrated 1:25-1:100 0.1 ml
BSB 2793 Concentrated 1:25-1:200 0.5 ml
BSB 2794 Concentrated 1:25-1:100 1.0 ml
BSB 2795 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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