IHC of Cytokeratin LMW/AE1 on an FFPE Prostate Tissue

IHC of Cytokeratin LMW/AE1 on a FFPE Prostate Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: the low-weight, acidic Type I cytokeratins and the high-weight, basic or neutral Type II cytokeratins. Cytokeratins are usually found in pairs comprising a Type I cytokeratin and a Type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue-specific. Cytokeratin Low Molecular Weight AE1 can recognize most acidic keratins, making it a broadly reactive antibody that stains most epithelia and their neoplasms. Members of the acidic and basic subfamilies are found in pairs. Each epithelium contains at least one acidic and one basic keratin so this antibody can show the distribution of keratin-containing cells in epithelia. Cytokeratin AE1 is particularly suited to distinguish poorly-differentiated Carcinomas from non-epithelial Neoplasms. This marker stains both normal and neoplastic cells of epithelial origin.
Antibody Type Mouse Monoclonal Clone AE1
Isotype IgG1 Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Prostate, Salivary Gland, Bladder, Breast, Kidney, Pancreas, Cervix
Presentation Cytokeratin LMW AE1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5435 Prediluted Ready-To-Use 3.0 ml
BSB 5436 Prediluted Ready-To-Use 7.0 ml
BSB 5437 Prediluted Ready-To-Use 15.0 ml
BSB 5438 Concentrated 1:100-1:500 0.1 ml
BSB 5439 Concentrated 1:100-1:500 0.5 ml
BSB 5440 Concentrated 1:100-1:500 1.0 ml
BSB 5441 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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