IHC of Cytokeratin 35BetaH11 on an FFPE Prostatic Adenocarcinoma

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratin 8 belongs to the Type II (basic) subfamily of high molecular-weight keratins and exists in combination with cytokeratin 18. Cytokeratin 8 is primarily found in the non-squamous epithelia and is present in the majority of Adenocarcinomas and Ductal Carcinomas. It is absent in Squamous Cell Carcinomas. Hepatocellular Carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18. Anti-Cytokeratin 8/35βH11 stains most Non-Squamous Epithelial tumors; Squamous tumors are negative for this antibody as a rule. This antibody stains Adenocarcinomas of the breast, ovary, gastrointestinal tract, thyroid, pancreas, bile duct, and salivary glands. This antibody does not react with skeletal muscle or nerve cells.
Antibody Type Mouse Monoclonal Clone 35βH11
Isotype IgM Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Prostate, Colon
Presentation Cytokeratin 8/35βH11 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 5421 Prediluted Ready-To-Use 3.0 ml
BSB 5422 Prediluted Ready-To-Use 7.0 ml
BSB 5423 Prediluted Ready-To-Use 15.0 ml
BSB 5424 Concentrated 1:50-1:200 0.1 ml
BSB 5425 Concentrated 1:50-1:200 0.5 ml
BSB 5426 Concentrated 1:50-1:200 1.0 ml
BSB 5427 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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