IHC of Cytokeratin 5 & 6 on an FFPE Mesothelioma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratin 5 (58 kDa) is a high-molecular weight, basic type of cytokeratin expressed in basal, intermediate and superficial-cell layers of stratified epithelia as well as transitional epithelia, complex epithelia, mesothelial cells and Mesothelioma. Cytokeratin 6 (56 kD) is also a high-molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with Cytokeratin 16.
CK 5 and 6 are positively seen in nearly 100% of Malignant Mesotheliomas and are rarely seen in Lung Adenocarcinomas. CK 5 and 6 can positively be seen in undifferentiated Large-cell Carcinoma as well as Squamous Carcinoma. Fewer than 10% of Carcinomas of the breast, colon, and prostate stain positively for this marker. CK 5 and 6 have also been used successfully as a myoepithelial cell marker in the prostate to determine malignancy.
Antibody Type Rabbit Monoclonal Clone EP24/EP67
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Mesothelioma, Prostate
Presentation CK5/6 is a rabbit monoclonal cocktail antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6604 Prediluted Ready-To-Use 3.0 ml
BSB 6605 Prediluted Ready-To-Use 7.0 ml
BSB 6606 Prediluted Ready-To-Use 15.0 ml
BSB 6607 Concentrated 1:25-1:100 0.1 ml
BSB 6608 Concentrated 1:25-1:100 0.5 ml
BSB 6609 Concentrated 1:25-1:100 1.0 ml
BSB 6610 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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