IHC of Cytokeratin 4 on an FFPE Oral Mucosa Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratin 4 is a type II cytokeratin and is specifically found in differentiated layers of the mucosal and esophageal epithelia together with Cytokeratin 13. Mutations in the genes encoding this protein (KRT4) have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.
A decreased expression of CK4 is associated with head and neck squamous carcinoma. It is helpful in the differentiation of squamous cell carcinoma of esophagus origin from that of thyroid origin.
Antibody Type Rabbit Monoclonal Clone EP4
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Cornea, Anus, Larynx, Pharynx, Tongue, Prostate, tonsil, Cervix, Squamous Epithelium, of Esophagus, Cervical Squamous Carcinomas
Presentation CK4 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6590 Prediluted Ready-To-Use 3.0 ml
BSB 6591 Prediluted Ready-To-Use 7.0 ml
BSB 6592 Prediluted Ready-To-Use 15.0 ml
BSB 6593 Concentrated 1:25-1:100 0.1 ml
BSB 6594 Concentrated 1:25-1:100 0.5 ml
BSB 6595 Concentrated 1:25-1:100 1.0 ml
BSB 6596 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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