IHC of CK 14 on an FFPE Cervical Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Cytokeratin 14 is a Type I polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. It is usually found as a heterotetramer with two cytokeratin 5 molecules, and a Type II keratin. Together, they form the cytoskeleton of epithelial cells. Mutations in the genes for these cytokeratins are associated with Epidermolysis Bullosa Simplex. Cytokeratin 14 has been studied as a prognostic marker in Breast Cancer. This antibody labels the basal layer of stratifying squamous and non-squamous epithelia. The staining pattern is cytoplasmic. It recognizes Basal Cell Carcinomas and Squamous Cell Carcinomas. Anti-CK14 has been demonstrated to be useful in differentiating Squamous Cell Carcinomas from other epithelial tumors. This antibody has also been useful in separating oncocytic tumors of the kidney from renal mimics, as well as in determining metaplastic Carcinomas of the Breast.
Antibody Type Mouse Monoclonal Clone EP61
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Squamous Mucosa, Prostate, Breast, Tonsil, Salivary Gland, Skin, Cervix Carcinoma, Squamous Carcinoma
Presentation Cytokeratin 14 RMab is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6681 Prediluted Ready-To-Use 3.0 ml
BSB 6682 Prediluted Ready-To-Use 7.0 ml
BSB 6683 Prediluted Ready-To-Use 15.0 ml
BSB 6684 Concentrated 1:50-1:200 0.1 ml
BSB 6685 Concentrated 1:50-1:200 0.5 ml
BSB 6686 Concentrated 1:50-1:200 1.0 ml
BSB 6687 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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