IHC of CLusterin/Apoliprotein J on an FFPE Tonsil Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation The Clusterin protein, also known as Apolipoprotein J, is a 75-80 kDa disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid. It is a stress-induced cytoprotective chaperone protein regulated by HSF1 and functions similarly to a small heat-shock protein. Clusterin is distributed widely in human tissues and fluids, including normal epithelial cells, plasma, cerebrospinal fluid, breast milk, semen and urine. Clusterin has been implicated in a variety of activities including programmed cell death, regulation of complement mediated cell lysis, membrane recycling, cell-cell adhesion, and src induced transformation. As part of the attack complex of complement, it acts as a complement inhibitor.
Clusterin is expressed in a wide variety of hematopoietic and non-hematopoietic tumors. Overexpression of Clusterin is associated with poor prognosis in breast cancer and chemosensitivity in cervical cancer.
Antibody Type Rabbit Monoclonal Clone EP181
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic Control Tonsil, Lymph Node, Placenta, Colon, Kidney, Brain, Liver
Presentation Clusterin is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 6569 Prediluted Ready-To-Use 3.0 ml
BSB 6570 Prediluted Ready-To-Use 7.0 ml
BSB 6571 Prediluted Ready-To-Use 15.0 ml
BSB 6572 Concentrated 1:25-1:100 0.1 ml
BSB 6573 Concentrated 1:25-1:100 0.5 ml
BSB 6574 Concentrated 1:25-1:100 1.0 ml
BSB 6575 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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