IHC of Claudin-5 on an FFPE Liver Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation Claudin-5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin-5 have been found in patients with velocardiofacial syndrome.
Claudin-5 labels endothelial cells and has been used as a marker for endothelial lesions. Claudin-5 is also found in bronchial and lung epithelial cells. In tumors, Claudin-5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior.
Antibody Type Rabbit Monoclonal Clone EP224
Isotype IgG Reactivity Paraffin, Frozen
Localization Membranous Control Liver, Vascular Tissue, Placenta, Colon, Kidney, Fallopian Tube
Presentation Claudin-5 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2398 Prediluted Ready-To-Use 3.0 ml
BSB 2399 Prediluted Ready-To-Use 7.0 ml
BSB 2400 Prediluted Ready-To-Use 15.0 ml
BSB 2401 Concentrated 1:25-1:100 0.1 ml
BSB 2402 Concentrated 1:25-1:100 0.5 ml
BSB 2403 Concentrated 1:25-1:100 1.0 ml
BSB 2404 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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