IHC of Cytokeratin 6 on an FFPE Cervical Cancer Tissue
|Intended Use||For In Vitro Diagnostic Use|
|Summary and Explanation||Cytokeratin 6 is a type II cytokeratin known for its strong induction in stratified epithelia that features an enhanced cell proliferation rate or abnormal differentiation during wound healing in several diseases (such as psoriasis, actinic keratosis) and in cancer. It can be found on stratified epithelia including oral mucosa, esophagus, basal layer of epidermis, the outer root sheath of hair follicles, and in glandular epithelia.
Together, CK 5 & 6 can be used to differentiate Mesothelioma (positive) from Lung Carcinoma (negative) or metastatic carcinoma (negative), and can also be used to distinguish between Ductal Hyperplasia of the breast (positive) from Solid Papillary DCIS (negative).
|Antibody Type||Rabbit Monoclonal||Clone||EP67|
|Localization||Cytoplasmic||Control||Oral Mucosa, Esophagus, Skin, Glandular Epithelia|
|Presentation||CK6 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.|
|Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.|