IHC of CDK2 on an FFPE Lymphoblastic Lymphoma Tissue

IHC of CDK2 on an FFPE Lymphoblastic Lymphoma Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation CDK2 (also known as Cyclin-dependent kinase 2 or cell division protein kinase 2) is a 33 kDa enzyme that in humans is encoded by the CDK2 gene on Chromosome 12. CDK2 is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the cellular G1/S transition.Studies indicate that over expression of CDK2 may cause the abnormal regulation of cell-cycle, which would could directly contribute to hyper-proliferation of cancerous cells. HOX genes, which play a key role in cell differentiation and morphogenisis, are regulated by CDK2. Studies have shown that HOXA7 promoted cell proliferation (mediated by cyclin E1/CDK2) is evident in cases of Hepatocellular carcinoma, indicating that CDK2 may prove to be a useful marker in such cases.
Antibody Type Rabbit Monoclonal Clone RBT-CDK2
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Nuclear Control Testis, Tonsil, Prostate
Presentation CDK2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, fi lter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2636 Prediluted Ready-To-Use 3.0 ml
BSB 2637 Prediluted Ready-To-Use 7.0 ml
BSB 2638 Prediluted Ready-To-Use 15.0 ml
BSB 2639 Concentrated 1:25-1:100 0.1 ml
BSB 2640 Concentrated 1:25-1:100 0.5 ml
BSB 2641 Concentrated 1:25-1:100 1.0 ml
BSB 2642 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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