IHC of CD8 on an FFPE Spleen Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule that is specific for the Class I MHC protein. To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. CD8 is a T-cell marker for the detection of cytotoxic/suppressor cells of blood lymphocytes. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null cells and bone marrow cells. This antibody is used to distinguish between reactive and neoplastic T-cells.

Antibody Type Rabbit Monoclonal Clone EP334
Isotype IgG Reactivity Paraffin, Frozen
Localization Membranous Control Tonsil, Lymph Node, Liver, Colon
Presentation CD8 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2845 Prediluted Ready-To-Use 3.0 ml
BSB 2846 Prediluted Ready-To-Use 7.0 ml
BSB 2847 Prediluted Ready-To-Use 15.0 ml
BSB 2848 Concentrated 1:50-1:200 0.1 ml
BSB 2849 Concentrated 1:50-1:200 0.5 ml
BSB 2850 Concentrated 1:50-1:200 1.0 ml
BSB 2851 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.
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